{"id":42355,"date":"2024-09-11T14:54:36","date_gmt":"2024-09-11T12:54:36","guid":{"rendered":"https:\/\/dutchmicrodosing.com\/blog\/is-natural-psilocybin-more-effective-than-synthetic-variants\/"},"modified":"2025-11-25T17:14:55","modified_gmt":"2025-11-25T16:14:55","slug":"is-natural-psilocybin-more-effective-than-synthetic-variants","status":"publish","type":"post","link":"https:\/\/dutchmicrodosing.com\/en\/blog\/is-natural-psilocybin-more-effective-than-synthetic-variants\/","title":{"rendered":"Is natural psilocybin more effective than synthetic variants?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"42355\" class=\"elementor elementor-42355 elementor-42347\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-52216a3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52216a3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fc8e458\" data-id=\"fc8e458\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b9f147b elementor-widget elementor-widget-text-editor\" data-id=\"b9f147b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Synthetic variants are often used when researching the effects of psilocybin, but are they as effective as natural psilocybin? Specific research has now been done on this and it turns out that nothing beats Mother Nature after all. In this blog, we discuss the results of this study.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-81779c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"81779c4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b48e05e\" data-id=\"b48e05e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5292d4e elementor-widget elementor-widget-heading\" data-id=\"5292d4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Natural psilocybin vs synthetic<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b6aa65 elementor-widget elementor-widget-text-editor\" data-id=\"6b6aa65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Synthetically produced psilocybin is often used for research. This gives the most reliable results. But the question, of course, is whether it is as effective. Scientists at the Hebrew University of Jerusalem&#8217;s Hadassah Medical Center BrainLabs Center for Psychedelic Research decided to <a href=\"https:\/\/www.nature.com\/articles\/s41380-024-02477-w?_ga=2.81308049.76043924.1723707578-642854009.1719913477\">research<\/a> this. The goal was to find out if there was any difference in effects of natural psilocybin (from <a href=\"\/magic-mushrooms\/\">magic mushrooms<\/a>) and synthesized psilocybin.<\/p><p>Anecdotal and clinical reports show that natural psilocybin has unique effects that are qualitatively and quantitatively different from chemical psilocybin. The team of scientists now wanted to test exactly how this was done. The results could have important implications for scientific research.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-96c0702 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"96c0702\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4368293\" data-id=\"4368293\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-58b20f5 elementor-widget elementor-widget-heading\" data-id=\"58b20f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What is the influence of the entourage effect?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f98bbda elementor-widget elementor-widget-text-editor\" data-id=\"f98bbda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Those who study mind-altering drugs are certainly familiar with the entourage effect. This effect results from the <a href=\"https:\/\/dutchmicrodosing.com\/en\/blog\/what-substances-are-in-paddos\/\">combination of substances in magic mushrooms<\/a>, both psychoactive and non-psycoactive, which have an effect on each other&#8217;s actions. Different substances can enhance or even alter the action of other substances.<\/p><p>But this does not happen when psilocybin is manufactured by humans. Then only the main psychoactive compound is isolated, psilocybin, without the other compounds found in magic mushrooms. That does make the effects more predictable, which normally makes the entourage effect impossible.<\/p><p>The scientists indicate that in Western medicine, it was usually preferred to isolate active ingredients, rather than using extracts. This simply gives them more control over dosage and predicted effects. When natural products are used, it becomes much more difficult to get consistent results.<\/p><p>Therapies involving natural remedies involve the use of whole extracts or complete products, such as magic mushrooms. In that case, the operation may still be slightly different. In Western medicine, the entourage effect is well known and more and more research is now being done on it.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-57bf802 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"57bf802\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6123077\" data-id=\"6123077\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-661facb elementor-widget elementor-widget-image\" data-id=\"661facb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics.jpeg\" class=\"attachment-full size-full wp-image-42363\" alt=\"\" srcset=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics.jpeg 1024w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics-300x300.jpeg 300w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics-150x150.jpeg 150w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics-768x768.jpeg 768w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics-600x600.jpeg 600w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/psychedelics-100x100.jpeg 100w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f0f45b3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f0f45b3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-24f2f7f\" data-id=\"24f2f7f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b3a2c78 elementor-widget elementor-widget-heading\" data-id=\"b3a2c78\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The design of the study on the differences between natural and synthetic psilocybin<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a401a42 elementor-widget elementor-widget-text-editor\" data-id=\"a401a42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mice were used for the study. They were divided into three groups: one received a natural psilocybin extract, another the synthetic version and the third received a placebo in the form of a saline solution. The mice given the psilocybin (natural or synthetic) were given a dose that would be comparable to a therapeutic dose in a human.<\/p><p>The behavior of the mice was examined to assess the effects of psilocybin. The &#8220;head twitch response assay&#8221; was used for this purpose. From these head movements, the scientists can tell if the mice are under the influence of the psilocybin. After treatment, metabolic changes in the frontal cortex were also compared. The expression of synaptic proteins in the brain was also assessed. These are indications that <a href=\"https:\/\/dutchmicrodosing.com\/en\/blog\/boost-your-intelligence-with-microdosing\/\">neuroplasticity<\/a> is present in the brain.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f49b063 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f49b063\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-721c83b\" data-id=\"721c83b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1141ab2 elementor-widget elementor-widget-heading\" data-id=\"1141ab2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The power of natural psilocybin<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1baeb97 elementor-widget elementor-widget-text-editor\" data-id=\"1baeb97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>According to the researchers, the natural mushroom extract appears to have a more powerful and long-lasting effect on the brain than the synthetic one. As a result, natural psilocybin would carry unique therapeutic benefits that synthetic variants cannot match. After analysis, the metabolic profiles of the synthetic version and the natural extracts were also found to differ significantly.<\/p><p>Although there were differences at a deeper level, it seems that at the behavioral level the response was similar. The head movements were pretty much the same. One of the researchers, Professor Lerer, says: &#8220;We were surprised that there were no differences in the acute effects, evidenced by the head twitch response, between the chemical and natural psilocybin. But there were differences in the long-term effects on synaptic proteins. This does have important implications clinically.&#8221;<\/p><p>So it does appear that natural psilocybin is preferable in most cases. But for research purposes, synthetic psilocybin may be easier to use. That can give better predictable and more consistent results. The researchers indicate that if natural extracts are more potent, then it may be worthwhile to cultivate natural psilocybin that will give consistent results. This can possibly be achieved through careful cultivation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0ff1b97 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0ff1b97\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d3afbf6\" data-id=\"d3afbf6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c671fa1 elementor-widget elementor-widget-image\" data-id=\"c671fa1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms.jpeg\" class=\"attachment-full size-full wp-image-42369\" alt=\"\" srcset=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms.jpeg 1024w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms-300x300.jpeg 300w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms-150x150.jpeg 150w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms-768x768.jpeg 768w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms-600x600.jpeg 600w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2024\/09\/mushrooms-100x100.jpeg 100w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d4bdd1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d4bdd1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2c41d4d\" data-id=\"2c41d4d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ead7150 elementor-widget elementor-widget-heading\" data-id=\"ead7150\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Using natural psilocybin yourself<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0883e86 elementor-widget elementor-widget-text-editor\" data-id=\"0883e86\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>If you are looking to grow mushrooms, check out our grow kits in our webshop. This makes it very easy to grow your own mushrooms at home, to take advantage of that wonderful natural psilocybin whenever you want. You can use them as a recreational drug, but also to support your <a href=\"https:\/\/dutchmicrodosing.com\/en\/blog\/posttraumatische-stressstoornis-wat-is-het-en-wat-kun-je-doen\/\">(mental) health<\/a>. With a grow kit, you can likewise grow mushrooms for <a href=\"https:\/\/dutchmicrodosing.com\/en\/what-is-microdosing\/\">microdosing<\/a>. Mushrooms can be dried and frozen, so you can store them for a very long time.<\/p><p>If you are still a beginner in the field of mind-altering substances, it is best to choose a mushroom with a mild effect, such as the <a href=\"https:\/\/dutchmicrodosing.com\/en\/magic-mushrooms\/fresh-mushrooms-growkits\/mexican-xp\/\">Mexican<\/a> or the <a href=\"https:\/\/dutchmicrodosing.com\/en\/magic-mushrooms\/all-in-one-growkits\/b-all-in-one-growkit\/\">B+<\/a>. If you already have more experience, you can go for the <a href=\"https:\/\/dutchmicrodosing.com\/en\/magic-mushrooms\/fresh-mushrooms-growkits\/ecuador-xp\/\">Ecuadorian<\/a> or the <a href=\"https:\/\/dutchmicrodosing.com\/en\/magic-mushrooms\/mystic-fungi-grow-kits\/jack-frost-paddo-grow-kit\/\">Jack Frost<\/a>, for example.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Synthetic variants are often used when researching the effects of psilocybin, but are they as effective as natural psilocybin? Specific research has now been done on this and it turns out that nothing beats Mother Nature after all. In this blog, we discuss the results of this study. Natural psilocybin vs synthetic Synthetically produced psilocybin [&hellip;]<\/p>\n","protected":false},"author":3545,"featured_media":42349,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[104],"tags":[],"class_list":["post-42355","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.4 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Is natural psilocybin more effective than synthetic variants? - Dutchmicrodosing<\/title>\n<meta name=\"description\" content=\"Is natural psilocybin more effective than synthetic variants? 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