{"id":45128,"date":"2025-02-12T10:15:08","date_gmt":"2025-02-12T09:15:08","guid":{"rendered":"https:\/\/dutchmicrodosing.com\/blog\/microdoseren-met-psilocybine-of-cannabis-wat-zijn-de-verschillen\/"},"modified":"2025-10-30T22:37:00","modified_gmt":"2025-10-30T21:37:00","slug":"microdoseren-met-psilocybine-of-cannabis-wat-zijn-de-verschillen","status":"publish","type":"post","link":"https:\/\/dutchmicrodosing.com\/en\/blog\/microdoseren-met-psilocybine-of-cannabis-wat-zijn-de-verschillen\/","title":{"rendered":"Microdosing with psilocybin or cannabis: what are the differences?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"45128\" class=\"elementor elementor-45128 elementor-45120\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2562ee1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2562ee1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5fa9a79\" data-id=\"5fa9a79\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42e90d1 elementor-widget elementor-widget-text-editor\" data-id=\"42e90d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Microdosing has been gaining popularity in recent years, especially with psilocybin from magic mushrooms or truffles. But what about cannabis? Cannabis contains several cannabinoids, such as THC and CBD, which can potentially affect mental health and well-being.<\/p><p>Yet these two drugs differ significantly in action, dosage and effect on the body. In this blog, we dive into the similarities and differences between microdosing with psilocybin and cannabis, focusing on current scientific understanding and potential risks.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9655b4a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9655b4a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-16a7927\" data-id=\"16a7927\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1727cf6 elementor-widget elementor-widget-heading\" data-id=\"1727cf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What is microdosing?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec598f elementor-widget elementor-widget-text-editor\" data-id=\"8ec598f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Microdosing involves taking a very small dose of a psychoactive substance so that you experience the possible positive effects, but not the hallucinations or narcotic effects. Most commonly, microdosing is done with psilocybin from <a href=\"\/magic-mushrooms\/\">magic mushrooms<\/a> or <a href=\"\/psilocybine-truffels\/\">truffles<\/a>, but some people also experiment with other substances, such as LSD and cannabis.<\/p><p>Microdosing is being investigated for potential benefits such as:<\/p><ul><li>Improved focus and creativity (Cameron et al., 2020).<\/li><li>Slightly increased sense of well-being (Prochazkova et al., 2018).<\/li><li>Possible effect on <a href=\"https:\/\/dutchmicrodosing.com\/en\/blog\/how-microdosing-can-help-with-depression\/\">depressive symptoms<\/a> (Anderson et al., 2019).<\/li><\/ul><p>Important to know: scientific research on microdosing is still in its infancy. Although positive experiences are being shared, many effects have not yet been adequately proven in clinical studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cfb15e0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cfb15e0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-637f566\" data-id=\"637f566\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c57ccc1 elementor-widget elementor-widget-heading\" data-id=\"c57ccc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Similarities between microdosing with cannabis and psilocybin<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a428909 elementor-widget elementor-widget-text-editor\" data-id=\"a428909\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>1. Finding the right dosage is personal<\/h3><p>Whatever drug you choose, finding your optimal dose (called the <em>sweet spot<\/em>) takes time. This is because:<\/p><ul><li>Everyone has a unique metabolism.<\/li><li>Factors such as lifestyle, diet and genetics play a role.<\/li><li>Cannabis and psilocybin act on different receptor systems in the brain.<\/li><\/ul><p>In psilocybin, serotonin plays a major role, while in cannabis, the endocannabinoid system (ECS) is involved. This system regulates processes such as mood, sleep and pain (Lu &amp; Mackie, 2016).<\/p><h3>2. Personal experience varies by individual<\/h3><p>There are many anecdotal stories of people experiencing positive effects from microdosing. For example, some people report:<\/p><ul><li>Less anxiety and stress.<\/li><li>More clarity and focus.<\/li><li>A better mood.<\/li><\/ul><p>Still, it is important to take your own experiences seriously and not rely blindly on other people&#8217;s stories. What works for one person may not necessarily have the same effect for another.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-43ea137 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"43ea137\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-312e41b\" data-id=\"312e41b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0919a48 elementor-widget elementor-widget-image\" data-id=\"0919a48\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1792\" height=\"1024\" src=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129.webp\" class=\"attachment-full size-full wp-image-45140\" alt=\"cannabis\" srcset=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129.webp 1792w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129-300x171.webp 300w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129-1024x585.webp 1024w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129-768x439.webp 768w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129-1536x878.webp 1536w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/5c73dc82-80bf-46f4-b396-8c1830d65129-600x343.webp 600w\" sizes=\"(max-width: 1792px) 100vw, 1792px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0fd797e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0fd797e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-99b57ef\" data-id=\"99b57ef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-03e31bd elementor-widget elementor-widget-heading\" data-id=\"03e31bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The differences between microdosing with cannabis and psilocybin<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7373342 elementor-widget elementor-widget-text-editor\" data-id=\"7373342\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>1. Mechanism of action and chemical complexity.<\/h3><ul><li>Psilocybin is a psychedelic drug that is converted in the body to psilocin, a substance that binds to serotonin receptors in the brain. This affects emotions, consciousness and perception.<\/li><li>Cannabis contains hundreds of compounds, including THC and CBD. These act on the endocannabinoid system, which plays a broader role in pain, inflammation, mood and appetite.<\/li><\/ul><p>It means that cannabis is much less predictable when microdosing than psilocybin. Psilocybin has a more consistent effect, while cannabis is highly dependent on the strain, THC\/CBD ratio and method of consumption.<\/p><h3>2. Dosing and ease of use<\/h3><ul><li>Psilocybin microdosing is relatively simple: the dose is weighed out and often taken in capsules. There are ready-made microdosing truffles that are easy to dose.<\/li><li>Cannabis microdosing is trickier: because each plant is different, the exact concentrations of THC and CBD can vary. In addition, the method of administration plays a role:<ul><li>Smoking\/vaping: Fast absorption, but difficult to dose.<\/li><li>Edibles: Delayed absorption, longer effect.<\/li><li>Tinctures: Better controllable, but still difficult to dose.<\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cd5c8e7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cd5c8e7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f05bb2c\" data-id=\"f05bb2c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2506b56 elementor-widget elementor-widget-image\" data-id=\"2506b56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1792\" height=\"1024\" src=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10.jpeg\" class=\"attachment-full size-full wp-image-45134\" alt=\"psilocybin microdosing\" srcset=\"https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10.jpeg 1792w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10-300x171.jpeg 300w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10-1024x585.jpeg 1024w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10-768x439.jpeg 768w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10-1536x878.jpeg 1536w, https:\/\/dutchmicrodosing.com\/wp-content\/uploads\/2025\/02\/38d45f7c-1cee-4143-bc0a-c123a10abb10-600x343.jpeg 600w\" sizes=\"(max-width: 1792px) 100vw, 1792px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4107472 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4107472\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c69bfa4\" data-id=\"c69bfa4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1e954b8 elementor-widget elementor-widget-heading\" data-id=\"1e954b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Is cannabis suitable for microdosing?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a32519 elementor-widget elementor-widget-text-editor\" data-id=\"1a32519\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Although cannabis microdosing is possible, it brings additional challenges. Compared to psilocybin:<\/p><ul><li>Is the dosage less accurate.<\/li><li>Are the effects less predictable.<\/li><li>Is there less scientific research on the benefits.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e133ca1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e133ca1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ca75d38\" data-id=\"ca75d38\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0157a4e elementor-widget elementor-widget-heading\" data-id=\"0157a4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Want to start microdosing<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24cf7f2 elementor-widget elementor-widget-text-editor\" data-id=\"24cf7f2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Microdosing with both psilocybin and cannabis can have interesting effects, but there are important differences in action, dosage and reliability. Psilocybin is more scientifically researched, while <a href=\"https:\/\/www.news-medical.net\/health\/What-are-Cannabinoids.aspx\">cannabis is more complex<\/a> to dose and less predictable.<\/p><h3>Resources<\/h3><ul><li>Anderson, B. T., et al. (2019). &#8220;Psilocybin-assisted therapy for depression: Evidence and mechanisms.&#8221; <em>Journal of Psychopharmacology<\/em>.<\/li><li>Blessing, E. M., et al. (2015). &#8220;Cannabidiol as a potential treatment for anxiety disorders.&#8221; <em>Neurotherapeutics<\/em>.<\/li><li>Carhart-Harris, R. L., et al. (2021). &#8220;Psilocybin for treatment-resistant depression: A randomized controlled trial.&#8221; <em>New England Journal of Medicine<\/em>.<\/li><li>Prochazkova, R., et al. (2018). &#8220;Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting.&#8221; <em>Psychopharmacology<\/em>.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Microdosing has been gaining popularity in recent years, especially with psilocybin from magic mushrooms or truffles. But what about cannabis? Cannabis contains several cannabinoids, such as THC and CBD, which can potentially affect mental health and well-being. Yet these two drugs differ significantly in action, dosage and effect on the body. In this blog, we [&hellip;]<\/p>\n","protected":false},"author":3545,"featured_media":45122,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[104],"tags":[],"class_list":["post-45128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.4 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Microdosing with psilocybin or cannabis: what are the differences? - Dutchmicrodosing<\/title>\n<meta name=\"description\" content=\"Microdosing with psilocybin or cannabis: what are the differences? 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